Lung Omics

Climate change is increasing the frequency and intensity of wildfires in British Columbia and prolonging allergy seasons through higher temperatures and rising carbon dioxide levels. These changes are worsening air quality and placing a growing burden on respiratory health, particularly for people living with asthma, chronic obstructive pulmonary disease (COPD), and those recovering from lung cancer.

This study investigates how two major climate-related air pollutants—wildfire smoke and airborne allergens—affect human lung cells at a molecular level. Using lung cells donated by individuals with and without respiratory disease, we recreate realistic exposure conditions in the laboratory and examine how cells respond to these environmental stresses.

By applying advanced genomic technologies, our research aims to identify the biological changes that make some people more vulnerable to climate-related air pollution than others. The knowledge generated through this work will help build a foundation for identifying at-risk populations and informing future strategies to prevent and treat pollution-related lung disease. Ultimately, this research supports efforts to protect respiratory health as climate change continues to shape our environment.

Research is supported by Genome BC.